Marksman Cellject Inc. provides systems (hardware and software) for automated cell manipulation. Marksman's systems are capable of injecting suspended cells (e.g., zebrafish embryos and mouse oocytes/embryos) and adherent cells (e.g., endothelial cells and HeLa cells) with nano- to femto-liter biomolecules, at a high speed, and with minimal human intervention.

The injection of a large number of cells (zebrafish embryos, mouse oocytes/embryos, and adherent cells) is required for applications such as embryonic development studies, mutation screening to identify gene functions, assisted reproduction, and molecule screening.

Marksman Cellject Inc. offers automated injection systems and embryo holding devices to meet the requirements of high throughput and high reproducibility to overcome the problems inherent in manual injection, such as human fatigue and large variations in success rates due to poor reproducibility.

Our approach fundamentally changes cell injection. The embryo holding devices reduce sample immobilization time from minutes to seconds. Based on motion control and computer vision techniques, the automated injection system operates at a high speed and provides a high success rate, survival rate, and phenotypic rate, capable of replacing/assisting a human operator for large-scale cell injection.

See an example demonstration video of automated zebrafish embryo injection. A paper published in PLoS ONE describing the system and performance is free for access at the journal's site.

See our recently released motorized rotational stage MR 805 for orienting biosamples under an inverted microscope.