Marksman Cellject Inc. provides systems (hardware and software) for automated
cell manipulation. Marksman's systems are capable of injecting suspended cells
(e.g., mouse/human oocytes/embryos and zebrafish embryos) with nano- to femto-liter
biomolecules or with single sperm, at a high speed, and with a high reproducibility
and minimal human intervention.
The injection of a large number of cells (zebrafish embryos and mouse/human
oocytes/embryos) is required for applications such as ICSI (intracytoplasmic
sperm injection), assisted reproduction, reproductive biology and embryonic
development studies, mutation screening to identify gene functions, and drug/molecule
Marksman Cellject Inc. offers automated injection systems and embryo holding
devices (disposable or reusable) to meet the requirements of high throughput
and/or high reproducibility to overcome the problems inherent in manual cell
manipulation, such as human fatigue and large variations in success rates due
to poor reproducibility.
Our approach fundamentally changes cell manipulation. The several designs of
cell holding devices reduce sample immobilization time from minutes to seconds.
Based on motion control and computer vision techniques, the automated injection
systems operate at a high speed and provides a high success rate, survival rate,
and phenotypic rate, capable of replacing/assisting a human operator for highly
reproducible cell manipulation.
See an example demonstration video of automated
zebrafish/mouse embryo injection. A paper published in PLoS ONE describing
one of our zebrafish systems is free for access at the
journal's site, and a paper published in PLoS ONE describing one
of our mouse systems can be downloaded
See our recently released
motorized rotational stage MR 805 for
orienting biosamples under an inverted microscope.